I'm not a mechanic and my information may not be that accurate. Having said that I don't think running a fuel tank dry is a good idea. My understanding is that a number of vehicles have their fuel pump located at the bottom of the tank and use fuel as a cooling medium for the pump. Running it dry or near dry doesn't leave an adequate amount of fuel surrounding the pump to cool it.
You indicated that " The tank is designed with a special sump in it that allows 100% of the fuel to be drawn from the tank." Maybe this design feature alleviates the fuel pump cooling concern. I don't know.
Also dirt, etc. in a fuel tank tends to settle at the bottom of a fuel tank...stuff you don't want in your fuel lines and further.