I have used Diesel Kleen pretty much ever since I bought my F250 used 7 years ago. The few tanks I skipped seemed to get a little poor milage. I use the Winter blend starting about now and the Summer blend starting in the Spring. It raises Cetane rating a little and I can make myself believe that it runs with less rattle when I use it. Yes I carry it with me in small pre-measured bottles that I fill from a large jug at home and I dump it in before I start pumping.
Do I needed it? I don't know, but it is cheap insurance. I have tried several other brands but have always come back to Diesel Kleen, available most everywhere.