I've been in my trailer when we've had 70+ gusts and even with the slide out it's not really a big deal. My nose is pointed to the West where most of our strong winds come from and my house and garage plus a substantial treeline protect it from the North so the second most common high winds that might affect it broadside aren't really a concern. So I'd agree with face it into the primary wind direction and shelter it if possible from your secondary wind direction.
As far as tornados, that's why most campgrounds have strong shower houses, get out of your trailer and into them as they'll offer infinitely more protection. If on the road find a gas station or fast food place and go into the walk-in cooler.