One of the things not mentioned is holding tanks. I have an old 11.5 foot non-slide 1988 Bigfoot TC. It has only about a 8 gallon black tank, 20 gallon gray tank and 20 gallons of water. With two people that are frugal with water and take quick showers every other day, three to four days off the grid is no problem. You can extend that by carrying a couple of five gallon water cans, if you can dump your gray on the ground.
We could tow a trailer with additional water, holding tank, and stuff. We prefer not, although we do frequently tow our Samurai. We do have empty storage spaces in our TC.
From what I understand, most newer TCs, especially those with a basement, have much larger tanks. But the price you pay is more weight (approx. 8.3 lbs/gal) and a TC 1 to 1-1/2 feet taller than a non basement TC. My truck is 2WD, with 19.5s. The TC is non-basement, but with an A/C and east/west bed. This puts my TC at 10'3". This can make a difference depending where you camp, and will effect side sway in gusty wind conditions.
From what I have seen, north/south cab overs with slide are about 12 to 18 inches taller than the east/west bed. The basement can easily add another 12 inches of height.
Regardless of what TC you get, there will be tradeoffs. From TT to TC will definitely change your driving habits as well as your camping style.
Wayne