Tires - Preferences?

I am running a Chevy diesel 3500 with a Northstar Laredo on the back. I do a little off-roading, but nothing radical. Mostly 4wd is for sand, mud and snow. I do drive some dirt roads with sharp rocks, like out to the Racetrack in Death Valley (I typically air down and go slow). I am looking for E rated tires that have some off-road ability, but are reasonably quiet and efficient on the highway. I know the two are often mutually exclusive but I thought I would ask.

Any recommendations or thoughts?