Yes, there are many members on here that are using that combo. Most love everything about them except the fuel economy. The biggest advice I have read was to try to get a truck with 4:10 gears instead of 3:73 gears. The lower gears improve city mileage, help it tow better, and only lower the mpg slightly. Same with the F250, get the 4:30 gears instead of the 3:73 gears.
This package was on my short list, but there were zero dealers that had one available.
Good luck