I have 30,000 mile of towing from IN to MT, IN to FL several times, IN to AZ plus several local trips (less than 1000 miles). As mentioned maintenance is key.
However, if you happen to have seen me on the side of the road with a smoking tire and assumed it was because it was underinflated, that is only partially true. The reason it was underinflated was because a road hazard put a baseball sized dent in the rim as it ruined both axels and broke a spring. Thank goodness for good insurance.
The point is even the best maintenance cannot prevent an unfortunate incident.
Be careful out there.