We have gone twice (so far!) from Connecticut to Florida.
I second the "50 miles per hour rule" for trip planning... I always average 65mph speed when towing, but at the end of the day, including rest stops and traffic, it always seems like when you divide the time towing with miles, it ends up being 50 miles per hour.
I plan on stopping for a quick break every 1 1/2 hours or so, and a longer break every 3 hours or so.
For total time, we were about 25 hours. 15 hours from Connecticut to South Carolina (we stayed in Florence, Florence RV Park - simple on and off I95, great for an overnight). Then 10 hours from South Carolina to Fort Wilderness, Disney.
Yes, there are restrictions regarding roads, tunnels, bridges, etc. I HIGHLY recommend figuring out a possible route, then post in a thread in these forums to get feedback from people.
When we went to Disney, the feedback I got from people on these forums was invaluable for trip planning. Most times you will get comments from people that may have been on your exact route just the day before.
I am a planner, so I had my route planned, and timed, carefully. I left extra time available for circumstances - longer stops, delayed start, traffic, etc. Don't let traffic get you down! It will happen, just turn up your air conditioning and the radio and enjoy not working. Your advantage is you don't have to worry about going through NYC / George Washington Bridge / Tappanzee Bridge!