Breaking the partial vacuum behind and under the TT probably would have a slight effect on air drag that is why you see it on many trucks.
However in the RV world few if any would consider it worthwhile. Let's suppose the various gizmos you added to your RV gained one half a mile per gallon. That is a substantial 5% improvement. So, instead of 10 mpg you got 10.5 mpg. With $3.20 gas you would save 1.5 cents /mi. so you would have to tow 10,000 miles to save $150.00.
Now with a Semi fleet at 8 mpg, an 8.5 change would be a bit over twice the savings and because of their mileage, it become a significant figure.
Waxing the RV does not improve mileage.