Having wider spacing enahnces directional stability which runs counter to the ability to turn. In other words the trailer naturally wants to continue in a straight line, and turning causes more tread scuffing. Now whether this difference (a foot maybe) is seen at the cab - probably only when travelling in windy conditions or when a semi blows by in the opposite direction.
As for loading on the frame - the wider the spacing the better, but again, with maybe a foot difference between closely spaced and widely spaced, the difference is probably negligible. I would expect that, in general, the longitudinal bending stress in the frame would lower with the wider spaced wheels, but I would have to see how the axles are attached to be sure.
Regarding chocking - spacing makes little difference, and if there was a difference in resisting rolling while chocked, it would favour the closer spaced wheels as the chock mechanism (whatever the design) would be more compact and less prone to racking loads.
With respect to bounce - wider spacing would only improve the teeter-totter effect, but given that the RV is hitched to the truck this effect may be a more sublte improvement in motion control. There is no significant differnce when driving over smooth terrain.
My 2 cents.