I've NEVER in the last 30 years gotten through Garita 2 San Ysidro in under 2 hours.
Otay is faster but over the last eleven trips using a clock and Boulevard 2000 (toll road) gotten in line faster than 32 thirty two minutes longer to get into line at San Ysidro. Record fast crossing at Otay was eleven minutes. Normal is 30 minutes to sixty minutes. Very normal 30 to 45 minutes plus 32 extra minutes to get there.
Pablo and I joke about the border wait times discrepancy all the time. Maybe doable in a vehicle with CPB decals in California POE's. Cardiologist appointments are sadly rather scarce between 4PM and 9AM.
Exhaust gasses, pavement temperature flares, and idiots convinced 40 lane changes an hour will save an hour are major obstacles.
Bumper Rubbing.
