We drove our 32' TT in from the West side and found plenty of very tight switch backs in one specific section before Groveland. Nice, new, wide roads. Still, they required very slow speed and caution.
We drove Tioga pass with only the SUV (it had finally opened just 1 day prior to our arrival...what timing) and while elevation was much higher with I did not find the roads any more difficult. And the drive was dramatically more gorgeous.
It's worth asking more people who have driven it with large RV's, but I personally did not feel it was any worse than entering/exiting on 120 from the West. Dare I say I would actually prefer entering/exiting from the East side???