If you are comfortable driving mountain roads, it would be okay. I have pulled my 43'FW over it, and would say the grade from Newfound Gap down to Cherokee is the grade to take your time on. Just long, but roomy. The bridge and the circle above Gatlinburg was picturesque to say the least, but 45' long tour buses negotiate it every day. I did have a jake brake, and manual trans when we did it. Gatlinburg is full of tourists, so use caution there, but at the time they were paving 441, and detoured us through town, so I'm sure it is way better now.