Best Route- New Mexico to Florida

All of the Interstate Highway system is busy with trucks. They will be moving at about the same pace you can maintain in a motorhome. So best route depends on where in New Mexico to where in Florida. Las Cruces to Jacksonville it would be I-10 all the way. Farmington to Sarasota or Miami, many interesting options, where you go east, where you start going south. From Albuquerque to almost anywhere in Florida I would choose the first route suggested by 2gypsies, because I have a lot of experience with the Mississippi section, although coming from NE Oklahoma I have a preference for staying on I-40 to Little Rock, then using I-530/US-65 to get down into western Mississippi to connect with US-49.

If you are coming from northern New Mexico and drive on only Interstate highways, you are in a real fix, as there are no connections on a NW to SE diagonal.