Best is a nebulous word. For me best would be the most back roads and very little interstate.
For others the interstates are a must
so I assume the interstates are your preference and so
75 to Dayton us 35 to 64 West Virginia pike to I77 to I74 to us 52 to I40
Kind of mountainous so you might want to consider
I80 to I81 to I83 to I95 to US64A take the loops around BAL and DC
more traffic less hills
Traveling with my best friend my wife!