We avoid interstates as much as possible. Mostly because they are so beat up, bumpy, and drivers are just insane, aggressive, and filled with road rage. Several years ago we decided to avoid the "fast lane" roads and travel state highways and US routes. Life has been much more pleasant.
Oh yea, we get a few more stop lights, a few more cross roads with 4 way stops, and we hit a few more small towns where the speed limits drop to 30 mph or less. Sometimes we get behind a farm tractor that simply too wide to pass and follow him for 7 miles (towing the trailer) ... which actually happened last weened end on our return home.
Sometimes we get stopped at rail road crossing and have to sit and wait! Imagine that? I suppose it could be worse, we could be sitting on an interstate in a traffic jam going zero mph too! At least at the rail road crossings, we can jump out of the truck, run back into the camper, use the bathroom, grab a drink and a snack and make it back into the truck before the train finishes crossing.
Then there's always the local yocals as I like to call them. By far, the local people who own and operate the local mom-and-pop shops, who have their own vested interest in their business are going to be nicer, calmer, and more cheerful, and will gladly take the time to talk to you about anything, it seems.
Now granted, sometimes you run into a real whac-o, who will go off on some tangent talking about his latest experience with Extra Terrestrial visitors from Mars or something, or the grandmother who just won't stop talking about her grandkids and how magnificent they are, but these come with the territory, if you venture to open a discussion.
Not to mention, almost all of those Mom-and-Pop restraunts have the best food imaginable, and usually don't cost near as much as McDonald's gut burger does these days.
Occasionally, run into Amish which are always willing to share stories with you, share their way of life, and of course, share their faith experiences too.
The USA still does have some fantastic people, lovable, friendly, and good that still care and truly do make this land a better place.
I agree completely ... take the back roads!