We drive up every second year. We fish. Generally leave DE around May 20, cross to Canada in western Montana, then up to Calgary, Edmonton and up. We stop for a few days in Tok and get the rig cleaned up, clothes washed, etc. Then down the Tok cutoff toward Glennallen. We fish that area if Kings are running and weather is good. THen a run to Valdez for a few weeks for early Pinks, shrimp and renewing old friendships. Later back to Copper Center for a week or so for Red Salmon and on to the Kenai for a run to Homer for Halibut out of that area.
Get a copy of the Milepost (1 year old is OK as the new one won't be out till March). Use that for your planning. What ever you do, don't miss any local museums or visitor centers. All are great. local docets have all the best info on local things to see. Fuel will be expensive but that's the cost of the trip. Check out local festivals and celebrations and talk to everyone. Most of those traveling will be Alaskans. They've been cooped up all winter and want to get out. Museums in Valdez, Fairbanks and Anchorage are also great. Tons of things to do and places to go. We do at least one new thing each trip and haven't run out yet. We've been up in '06, '07, '09. '11, '13 and will go again next year.
We leave around Sept 25th. 10 driving days of about 600 miles a day, but we've done our sightseeing along the route so we only stop to sleep. Roads north of Whitehorse will have frost heaves and some loose gravel, but if you just slow down, you'll be fine.
Needless to say we love it. We flew up in '11 for the Iditerod in March. Drove around for 2 weeks and loved it too. -38 just outside Denali, but we were fine. Be cautious though. THe place is addictive. Once is NOT enough.