We haven't driven it specifically but we have inadvertently covered most of it along with boating from St. Louis to the Ohio River
The north section is certainly more scenic.
- South section tends to be a lot of flat flood plains with the river behind levies with minimal access. New Orleans and the Delta are fun to visit but otherwise, not a ton that peaks our interest if you stick close to the river.
- North of St. Louis, the river takes on a different character as it now utilizes locks and dams to control it. You get a lot more bluffs and scenery. Up around Lacross is absolutely gorgeous.