You'll have no issue from Montrose to Ridgeway. From Ouray to Durango it is steep and curvy. If that would be a concern for you or you don't feel you've had mountain driving experience then take the alternate but longer route of Hwy 145 to Telluride and down to Cortez (Mesa Verde Nat'l Park) and east to Durango. It's also a beautiful drive.
We've made the drive from Ouray to Durango often with our 40' motorhome towing. However, we're used to mountain driving. We've never seen a vehicle crossing the center line..not saying it doesn't happen, but it hasn't happened to us. There are folks driving a straight two-lane highway in Kansas or wherever who can't stay in their lane either.
๐ No, it doesn't have shoulders or guardrails but then you're not supposed to drive on the shoulders.
Bottom line, if this road concerns you don't drive it but there are many others out there that love the drive. To say, definitely don't drive it is ridiculous.
Full-Timed for 16 Years
.... Back in S&B Again
Traveled 8 yr in a 40' 2004 Newmar Dutch Star Motorhome
& 8 yr in a 33' Travel Supreme 5th Wheel