Construction on the Atchafalaya Bridge, narrow lanes & lane shifts. Very rough road on I-10 through Sulphur even if you take I-210 around Lake Charles. Construction on I-10 through Orange right after you reach Texas.
I have started going on US190/LA12/TX12 north of I-10 from just east of Baton Rouge to Vidor, TX to avoid this. I jump over to US190 at LA415 at Port Allen and TX12 rejoins I10 in Vidor. You do go through some towns along the way, but I find it less stressful than the narrow interstate lanes.
There is still construction with narrow lanes on I10 near Winnie involving various sections of eastbound and westbound at various intervals. The only way to avoid this is catching US90 in Beaumont then taking FM365/FM1406 south at Nome to catch TX124 in Winnie for the Bolivar ferry.