I69 to 288 Houston

We've been going to the Med Center often here lately. Since the 288 toll road construction seems complete, the traffic has gotten much better. We usually hit it anywhere from 6am to 8am and again mid day going home. In the past I have even gotten off the freeway and driven through downtown.
I would just go for it. You have just as much a chance of getting in a jam on 59/69 inbound. You only have to move over 1 lane to the left around George Brown Convention Center then take the 288 exit.
But I've driven in Houston traffic since I got my license...1965.

"I bet they will mail you a bill." - They will

I69 south through town to 288 on a Saturday isn't too bad these days. Weekdays would certainly be bad. Northbound 288 to I69 exchange is still a mess any day of the week.

The I69 to 288 is not good but it's not as bad as it was before covid. There is the usual congestion at Minute Maid stadium & George Brown Center but it clears up before the 288 exit. Just take a deep breath and dive in.
How are you wanting to get to the Houston area from Tyler?
I would consider I59 to 99 to 6 to 288, or 36. 99 is toll with no booths. I bet they will mail you a bill.

You might consider this for your trip to Freeport from Tyler. It will avoid downtown Houston:

* Get to I-10 in the Baytown area by way of your preferred route from Tyler.
* Take the TX-146 exit south from I-10 right after the Old & Lost River/Trinity bridges. There's a few lights, then you reenter a freeway.
* Take TX-146 across the Houston Ship Channel bridge, then exit TX-225 west on past the San Jacinto monument.
* Take the I-610 south/west exit to loop around downtown to the TX-288 south in the Reliant Stadium area (the key phrase here is "around downtown.")
* There is some construction at the 610/288 interchange, but another earlier post has said it is complete now.

TX-288 is a freeway several miles south of the 610 interchange.

I like the High Island/Bolivar/San Luis Pass/Surfside route, but this will give you a change of scenery without as much traffic and hassle as going through downtown Houston.

Thanks everyone. Per Trip Planner the Madisonville route adds 2 1/2 hrs to our destination of Bluewater RV Park. We will be going that way home as we are stopping in Sealy to visit my Wife's Sister.
I'm not afraid of driving in heavy traffic . I just prefer to avoid it if at all possible when towing our 5er.

All the 288 construction is over. Traffic flows really well.
The only bottle neck is at the 69/ 288 exit. Usually a couple minute delay.

It won't add that much time for your dually and 5er, but the cross country route is easier. Just a bit of stopping.

Personally, I don't like 288 from downtown Houston out to Almeda-Genoa Road, but it is up to you. I've done Madisonville to Sealy several times, and other than a bit slow, it is a good road.