I've pulled our trailer over 79 & 206. 79 is no problem. 206 has some hills and curves, but the road is pretty smooth, and its not like a mountain pass out west or anything. I would guess 79/206 will save some time even with the MH and it is a pretty drive. 13 to 81 is going to be flatter but you'll also get the construction in Binghamton. If you prefer the mostly interstate route, its not that much longer.
Hopefully your MH rides a little smoother than our truck did on I-88. That road always has much less traffic than I-90, but the concrete joints were brutal!