Too soon to tell what the weather will be. An ice storm can come out of nowhere and move its way across AZ, NM, TX and screw up travel like it did for us a few years ago.
Taking I-8 into San Diego is a steep climb over the mountains to the east. I-8 might be less congested than I-10. I-40 is usually windy and is known for some terrible weather but coming from Neb you should be used to that, lol.
2013 Chevy 3500HD CC dually
2014 Voltage 3600 toy hauler
2019 RZR 1000XP TRE