From where you are if it weather forecast is iffy just take 87 to 78 and hit Harrisburg that way. The worst part of 81 is between Binghamton and south of Wilkes Barre, Pa. Northern Pennsylvania I81 can get icy and miserable specially at night. It is very hilly. There is a flying J to overnight in about 25 miles into Pennsylvania at Gibson exit. The road itself is in excellent condition until you get to the construction in Scranton.
The road between Scranton and Wilkes Barre is congested at times and is known for increased accidents and so has a lower speed limit for about 30 miles. I usually take the turnpike from Clark's Summit to Just past Wilkes Barre to avoid all the distractions. When you exit the Turnpike there are a couple of gas stations right at the exit. Weekdays this is a very good option to me so as to avoid all the construction
It is a pretty ride though.
I can remember within the past 5-6 years rerouting myself from Syracuse down the thruway to avoid I81 on miserable days.