It's been years since I've been on TN-68 from Tellico Plains to Ducktown. There aren't many choices to get from I-75 in Tennessee to Murphy NC/Blairsville GA. As I remember TN-68 is a good as any, and better than some others. Both the Cherohala Skyway & US-441 climb to over 4500'. US-129, aka the Tail of the Dragon. A pickup with 12' trailer you wouldn't have any problem, but it would be farther and slower. TN-68 is real good to Tellico Plains, and not any worse than any other from there to Ducktown TN.
2018 Silverado 3500 DRW
2011 Montana Mountaineer 285RLD