I don't know about the route you're proposing. We're in Rochester and use 390 which turns into Route 15. We've never had a problem towing a 5th wheel (12' tall) with 4 bikes on top of the truck. Google shows it adds less than 20 minutes and 20 miles to the trip from the Buffalo area. Of course Google's not always correct!
🙂
johnm
'13 GMC Serria D/A, CC, 4x4
'16 Forest River Vengeance 25V