If you're not in a hurry, take 65 south to Harrison Arkansas, then route 412 east. The road is a good 2-lane, twisty and hilly in the Ozarks, but quite doable with your setup. We did it in our 33 footer with toad and had no problems. Very scenic and relaxing and a lot of small towns. It eventually takes you to Jackson, TN where you can get on I40. We were heading to Birmingham, AL and took 2-lanes (can't remember routes) to Birmingham. Stayed off interstates as much as possible. Good Luck!