There are almost endless variations possible, but I will give you a "southern route" for comparison. I will use Macon, GA as a starting point and Colorado Springs as a destination.
Macon to Montgomery, AL mostly along US 80. Continue on US 80 to junction with I-20 near Meridian, MS. Follow I-20 across MS and LA into East Texas. Use either US 271 to Paris, TX or US 69 to Sherman, TX to get up to US 82. 82 is a good route along the Red River and avoid the traffic near Dallas/Fort Worth.
Near Wichita Fall, TX join US 287 to Amarillo then up to Dumas and US 87 on to Dalhart. Follow US 87/64 to Raton, NM. Pick up I-25 right into Colorado Springs.
I have towed every mile of this route (not all on the same trip) excecpt the first miles in Georgia. I have driven even that portion of the trip, but not towing.
There are campgrounds all along the way, several at Meridian and Vicksburg, MS. A nice state park, Roosevelt, at Morton, MS. Many public and private campgrounds in East Texas. Tyler State Park is not far off the freeway. We often stay at Ole Town Cotton Gin at Goodlett, TX, and there are several good campgrounds in Amarillo. We try to plan our trip to spend a night at the top of Raton Pass. A very nice RV park there now goes by the name Raton Pass RV. It would be an easy drive on to Colorado Springs.
If you are new to mountain driving, Raton Pass is a good beginner's experience, broad lanes to allow traffic to pass.
I just give this as one good example because I am very familiar with these roads. I do recommend US 82 and an alternative route across North Texas. It is the way we always go to Colorado now.
I'll be glad to respond to any questions and to give more specific suggestions about overnight stops along the way.
