I'll second the vote for the Sumitomo 17.5 inch tire.
16 inch trailer tires = Piece of Rubber interrupting your trip.
17.5 inch trailer tires = Peace of Mind enjoying your trip.
if you tow frequently many miles the average cost of your peace of mind drops with each mile towed.
As to the poster that talked to someone who said the 17.5 tire would be to hard on a fifthwheel the answer is to inflate the tire only enough to cover the actual weight on the tires plus the 20% safety factor.
Although the Sumi's max PSI is 125psi giving you 4800lbs cap I inflate mine to 105psi giving my 4065lbs cap which is more than enough for my trailer and softens the ride at the same time.
Just make sure you refer to the manufacturers inflation chart