It depends on the brand. We started shopping XLR Thunderbolts specifically because they have lighter pin weight compared to the identical floorplans from the competition. They do this by way of more forward placement of their axles. I didn't want a DRW so XLR it was. We tow our 395AMP with a 2012 SRW 350 6.7 SB and are completely satisfied with the way it tows. (Like and arrow that is.) Garage weight doesn't change the pin much so don't count on it to offset a pin too heavy for your truck. With 2000# in our garage, our pin only gets around 200# lighter. Our hauler weighs over 20k with the garage full and the water tanks full and with it's lighter pin we are still under on the trucks GVWR, GAWR, and tire ratings. We are over on GCWR but I've never been concerned with that. In the spring we are ordering a new 2017 SRW 350 and with it's new increased ratings, we will be under on GCWR too though.
Anyways, that was the long answer. The short answer is yes, it's perfectly doable if you find a large TH with a lower pin. Start with XLR. They are a great company making a great product that may well fit your needs.
Regards, Rodney
TV - 2017 F350 SRW CC SB 4X4 6.7
TH - 2015 FR XLR 395AMP