It seems to me like the area of the bed directly behind the cab is kind of a dead space anyway. I have noticed the loose end of a piece of rope will gently (as opposed to vigorously) blow around that area. It's also the best place to ride if your going to ride in the back. There is nothing causing resistance in that area to the truck moving forward down the road, so I wouldn't think covering it will matter at all. But things have to be tested in order to prove. I agree with "Old Biscuit," his idea will tell you the difference, if any, in wind resistance. Also it will change with vehicle speed, so if it were to be done, I would start measuring deceleration from the highest speed you can reach down to the instant vehicle falls below say 35mph.