Done both. For me anyway I like the ease of use of a 5th wheel. It tows very stable, no sway and no WD to fiddle with. More storage in the basement so that's where almost all of my stuff that went in the truck is loaded. I leave it there when we're done camping. Nicest feature about a 5th wheel and a truck is that you can walk between them when hitched. No trying to step over the coupler.
Cons. They cut the corner a little more than a TT. They're a little harder to back up. (Learning curve) and they're taller.
The 5th hitch can be a PITA to remove. B&W has a 2 pc hitch that's makes it a little easier. Anderson makes a really light weight one.
With that being said I could go back to a TT if it was the right one. Some out there like Grand Design and Outdoor RV have some really innovative floor plans and large front storage areas. And a TT is cheaper to buy. It's hard to give up all the storage inside and out along with the ease of use of a 5th wheel.
Kinda like towing with a diesel. Hard to go back to a gasser. Maintenance and repairs might be less on a gasser but the towing part isn't as nice.