for us, we keep our potable water tank full. if not used, we drain every month and refill and not to mention, don't forget to run the water, hot and cold to replenish what is in the lines. For me, a full tank with chlorinated water is better than an empty tank. it lessens the potential for bacteria growth. Flush and fill regularly and and you will be fine. If you have a concern, add a little chlorine/ bleach, maybe a 1/4 of a cup to 50 gallons, run fixtures, let sit for 24 to 48 hours, flush it all out and refill, you should be good to go. as far as filling when you get there, where are you getting the water and what quality does it have. Your city water should meet drinking water standards. we travel with full tanks all the time, drink it and use it for cooling and everything just like we are in our block home in the concrete jungle. Good Luck & Be Safe ! ! !