Could happen, especially if it wasn't hitched right or if the hitch wasn't installed correctly or if using some kind of adapter which added weakness.
In general though, physics dictates that scenario unlikely assuming everything is up to snuff. First, the hitch swings so any pressure pushing on the back would push on the hitch and take the path of least resistance. This would absorb energy as the trailer edges around the hitch. So energy would be spent there.
You also have the frame of the truck and on a long bed many feet of frame to go through. You would be more likely to see this happen on a short bed truck.
The front cap of an RV isn't exactly strong. Mostly fiberglass, resin and foam. So while it might look bad, hitting that isn't exactly like hitting something really solid. Again a lot of the energy of the impact would be lost when the fifth wheel cap hit the truck and literally started to crumple. Same is true for the front generator and storage areas.
When the two frames collide, tons of energy will be lost. I'd put my money on the truck frame over the fifth wheel frame any day.
So while I think this could happen, especially if you used some kind of adapter on a gooseneck or didn't install your hitch right, this type of accident would likely be super rare (they are) and serious injury would also be unlikely.
2019 Grand Design Momentum 395
2018 Ram 3500 DRW 4.10
2014.5 DRV Atlanta (sold)
2008 Newmar 4330 (Modified) Sold