Ford added 2" blocks above the axle (with new, longer Ubolts and prevailing torque flange nuts) to solve this problem.
And it is a common problem with F-450s and F-550's. More so with F-550's that are rated for a ton more carrying capacity.
Ford markets their solution with a name, called the "Anti-Rear Deflection Package"... something to that effect.
It is orderable with new trucks, but you can probably sleuth the part numbers for that option, order the parts, and have them installed.
The advantage to Ford's system is that it raises the rear without changing the spring rate... hence the ride quality should remain the same as what you are now experiencing.
The disadvantage depends on the type of bed you have. I'm assuming you have an F-450 cab chassis. If the cab chassis has pickup bed, then the disadvantage might be that you would have to raise the fiver higher on the landing gear to hitch up, but once the pin weight engages, the attitude of both truck and fiver should level out. If your cab chassis has a hauler bed or flat bed, then this is not an issue.
If your 2008 is an F-450 factory pickup, and not a cab chassis, then this entire "anti deflection package" solution is moot, since the F-450 pickup uses the F-350 frame and rear suspension geometry.