Long thread.
I used a gun several times and it saved my life. This was not in an RV but on a boat, over a 7 year period. Two times, I had to shoot (north Africa) and about 5 or 6 other times, the bad guys ran away when they saw the gun (Bahamas, central America and even US).
I was often in very remote or unusual places.
We now travel in an RV and we like remote places, the nature, forest etc. We have a shotgun in the RV and each carry a handgun.
Back to the OP:
If you mostly travel during the day, stay in nice campgrounds, there will be no more danger than during a normal sedentary life but if like me, you boondock often, stay in remote places and like to explore, I would recommend to become familiar with guns and get one.
I know people who were attacked, wife and daughter raped, others robbed and beaten and feel it is my moral duty to prevent that.
You should see the father who had his daughter raped, the saddest thing in the world.
We refuse to be victims, my wife and I carry responsibly.