For the most versatile camping lifestyle, a good truck and a truck camper works quite well. I full-timed in mine for over two years, and then later in life, Genie and I have taken six month trips at a time with no issues, even when it rains.
Best combo is a hard-side with full bath ... tight fit, but functional. Gets you clean. you'd need a 2500/250 truck for anything but the smallest, lightest. The difference between 1500/150 and 2500/250 in price is not significant, and you want enough power and suspension for comfort on the highways.
Drive into tight campsite, or tight forest or desert roads, and/or drop the TC at the campsite and take the truck alone.
We've been all over this country, Canada, and Mexico at various times - it goes anywhere we need, and the camper can go anywhere the truck can go ... no worries about turning around at the end of a road.
We'd suggest a 4x4 PU, as you only need 4x4 once to make it worth the cost, and it appears you like back-country rather than "Full HU" resort style.
If we know more about your budget, we can recommend a good set-up. Tires are important - and brakes - when hauling a TC as well.