I'll add our experience.
We retired fairly young about 15 years ago and started traveling fairly extensively. Much of that travel was in a 27" class C, usually towing a Jeep Wrangler. Over 13 years, we put 140,000 miles on that rig, including several multi-month trips. Early on my wife wanted to consider full-timing, but I liked to have a home base with a workshop, etc. We had a really wonderful home in central California, but did not have any strong emotional ties to it. On a long trip in 2104 we had a general agenda of places to visit before we had to get home to release our house sitters. During that trip, we were frustrated not to be able to really explore in depth areas we liked. It sort of dawned on us that we spending a fair expense maintaining a house for house sitters. By this time we knew we liked being together in a small space, and we really needed very little "stuff" to live, and I was ready to give up the headache and cost of maintaining a house. Talking to full-timers, we frequently heard the recommendation not to put anything in storage. We found we did not have any emotional attachment to most of the "stuff" in the house. What surprised us was the level of effort and logistics just to get rid of everything we weren't taking (from 40 years of home ownership). We eventually sold, donated, and just threw away what we did not intend to take. We decided that we needed more space and cargo capacity to be comfortable, and upgraded to a 39' diesel pusher towing a Jeep Grand Cherokee. We've been full-time for over a year (starting in our class C), and picked up our Class A DP last September. We are slowly adapting to life with little or no longer range planning.
In summary:
Make sure your partner is also your best friend and you like being close together most of the time.
That you are flexible and willing to adapt to changing conditions.
It is very helpful if you are handy and can manage minor repairs.
You have the financial resource to have an adequate exit plan whether voluntary or not.
Prescriptions and medical insurance are our biggest issues.
Art & Barbara
2016 Tiffin AB 37AP
2011 Jeep Grand Cherokee