I've never had an F53 Ford Class A, but have experience with 2 Ford chassis Class C's. The first was a '95 29' E350 Gulfstream with a super long for it's length 208" wheelbase. It also had all the tanks centered between the axles in the basement. For only a 12,200lb GVW chassis, basically running about 1,000lbs overloaded all the time, it handled very well, and much better when I added Bilstein shocks all around. Only slightly sensitive to winds and passing trucks and busses. The second and current RV, a '11 24' E450 Sunseeker, was bought on the heavier duty chassis to theoretically have way more weight-carrying capacity and drive better. Out-of-the box, not the case. The 24' floor plan requires the tanks to be further back, with the water tank under the rear corner bed, behind the axle. It took an alignment, a set of Bilsteins, and a monster sized front sway bar to get this thing improved. Now though, it is better than the older one, and it takes some extreme influence to move it around any. Happy pretty much at any speed, though the "settle in" MPH is around 67-68. That is where the happy confluence of forward progress and MPG is, at 8.0 even.
I also own an '11 6.7 diesel F250, and had to move my son 1,000 miles down on a Monday, and the same distance back on Wednesday a couple of weeks ago towing an apartment's worth of furniture and his stuff in my enclosed race car trailer behind that. 8,000lbs loaded and 5,000 empty. That was truly almost a don't even know it was back there experience. Cruise set at 72, 12mpg, the trailer, which has Torflex 5200lb axles didn't even have a hint of a wiggle, helped out by the Dual-Cam hitch I use. My Class C E450, and I assume an F-53 as well, being much more "raw" truck based, is just not as comfy to drive, and a lot more of a visceral kind of experience.
