In Southern Arizona, we have pack rats EVERYWHERE. They are very destructive. Give them the smallest opening, and they will try to get in. In the last week, I've trapped six of them using rat traps in the back yard right by the house.
They will get in your engine compartement and eat wires and and anything that is not metal. They bring in trash, and leave behind fleas and waste. In addition, since they are part of the food chain, they attract rattlesnakes and gila monsters.
However, they do not like to hide in places where there is light. In addition to placing rat traps around the vehicle, quite a few folks here put a mechanic's drop light or two in their engine compartment. The concept is that the rats will not want to nest in the engine compartment because of the light.
Just be careful with any traps that set so you don't hurt pets or kids. They are very powerful.