I have not owned one, but I have shopped them, and spent many (maybe thousands) of hours behind the wheel of most of the Class-5 offerings (Ford, Dodge, GMC, Freight-liner). Here's some of my observations:
Pros of a Class-5 Super-C
-Generally better engine noise reduction, except the Newmar Canyon Star I test drove was pretty good too. The GMC isn't great in that regard, but it hasn't been built in a long time anyways. I'm assuming you are shopping new. The Dodge 5500 is not as well sound insulated as their pickup counterparts but its good enough.
-Traditional overhead cab. The nicer Class As skip on the drop down bed (like the Newmar). The Class A's with a drop-down bed seem to be not very well put together (THOR).
-Service *should* be easier. At least the cab will be common with other trucks. However, you still run into the same limited dealer network as Class As do.
-More towing capacity. The Super Cs (except the GMC) can all handle 10,000 pounds vs 5,000 or 7,500 on the gas Class As.
Cons:
-The cab is too low. This one was pretty much a deal-breaker for me, at least for Ford F550 motorhomes. Dodge 5500s would be the same. Pickups have lower cabs than even the E-series vans. And, they have kick-up frames after the cab. This means the house it almost twice as tall inside as the cab, which means nobody in the back can see forward unless they lay on the floor. I'm pretty sure this would cause a lot of motion sickness with passengers, beside losing the ability to utilize the cab as living area since the seats are too low to swivel around (and, I don't think swivel seats are an option anyways).
If you are looking at larger Super Cs, such as a Freightliner M2 unit, then that point doesn't apply.
-Another con is the Bosch CP4 fuel pump used in the F550. I still don't trust it. Yes, it seems incidents are less frequent now, but the consequences of losing a fuel pump are too high IMO. Rams used the CP3 so that's not a concern there.
More of a neutral point: Don't expect a diesel Class C to be any faster. Yes, power deliver is smoother, and it makes less racket when its working hard. But the diesels still only make 300 horsepower in medium-duty trim. At least at lower elevations, the 3-valve V10 will be able to pull at higher speeds climbing hill most of the time, at least until about 4,000 feet when the altitude starts to become noticeable.
One more thought: The Ford and Ram 550/5500 have 19.5" wheels, vs the 22.5" wheels on the 22k and learger Class A's. larger tires generally ride smoother, and also will not be as close to capacity as the 19.5"s.
2000 Ford E450 V10 VAN! 450,000+ miles
2014 ORV really big trailer
2015 Ford Focus ST