If you know where you're going to stay, that would help. Murrell's Inlet in the south to Little River in the north is 40 miles long and lined with hotels, CGs and restaurants. It is "The Grand Strand".
My only time in an RV was at Ocean Lakes. They're directly next to Lakewood and Pirateland. There's also a KOA, but its on the wrong side of Business 17 from the beach. That's a four lane run across Bus. 17.
Restaurants: Avoid the all you can eat buffets. Everything is breaded and deep fried. Some of it is cooked the same day its served. They call it "Calabash Style", but there's more breading than seafood. OTOH, the restaurants in Calabash, NC. actually serve more seafood than breading.
If you don't want to stay on the beach, I'd recommend
Willow Tree About 10 miles north of Little River. Lots of space between sites, all face a large lake and many have private hot tubs.
BTW, if you're a golfer, take your clubs. Golf is a MB specialty. And if you get tired of seafood, try
Chuck's Steakhouse. Good steaks and salad bar, and a fishbowl full of "Chuck's Steakhouse" golf tees on the way out the door.
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Retired and visiting as much of this beautiful country as I can.