i will only run a plug to get home, on my motorcycle.
but for any car, pu truck, big rig. rv. no problem running a plug.
but best is to plug, and place a patch over it (inside the tire that is).
i have never had a plug, or patch fail. (40 years driving varied big rigs).
been driving for a living for almost 50 years, small trucks up to the classic "big rig". even on my personal cars, trucks. but have had tires fail do to other damage, or age.