IMO, the first consideration should be the modifications you are willing to do. I am not willing to do any mods! No, not even a lube pump or drive shaft disconnect! If that is also your feeling, then you are pretty much limited to a 4X4 with a Neutral position in the transfer case. Then you must read the Owners Manual to see if it is towable. If the instructions for towing are not in the manual, you can check with REMCO to see what they say.
The second consideration is the configuration you want or need. Can you get by with a standard cab (hard to find), or do you actually need an extended or quad cab? Keep in mind that the bigger the cab, the heavier the truck. The same goes for the truck bed or box. Do you need a long box, or will a short box do the job? Again, longer is heavier.
Third is "brand loyalty". For me, it would probably be a Dodge (or Ram, these days). Some people don't care, as long as it will do what they want it to do.
Oh, and of course, don't forget color! I wanted a red one, but the one I found was over $6000. I found a green one(nearly identical) that I was able to make a deal on for $3700. So, I have a green truck.
Have fun shopping.