New potential Parvo Treatment

[dturm]

Monoclonal antibodies have been in the news a lot with the COVID pandemic and their usefulness in treating disease.

Elanco (a large animal pharma company) announced purchase of the monoclonal antibody treatment for Parvo.

“With parvovirus on the rise, it’s more important than ever to bring a new treatment option to veterinarians for this devastating and deadly disease,” says Aaron Schacht, Elanco’s executive vice president of innovation, regulatory, and business development. “We’re excited to establish this important partnership with KindredBio to develop and commercialize this novel monoclonal antibody.”

KIND-030 is currently being pursued for two indications in dogs: prophylactic therapy to prevent clinical signs of CPV infection and treatment of established parvovirus infection. Completion of an upcoming pivotal efficacy study for the therapeutic indication is expected in the first quarter of 2021, Elanco says.

A study conducted by Kindred Biosciences earlier this year demonstrated 100 percent efficacy in the prevention of CPV, as well as a mortality benefit in the treated group

The only treatment we have had for this disease has been supportive in nature: fluid support, antibiotics and some have tried anti-virals with mixed success. This could be a game changer.

Doug, DVM

[dturm]

Lwiddis wrote:

And getting people to complete the series isn't easy I'll bet.

It's actually not as hard as you'd think. It seems that most people we deal with are more concerned with their pet's health than their own.

[Lwiddis]

"Until the series is completed dogs are still susceptible"

And getting people to complete the series isn't easy I'll bet.

[dturm]

The puppy vaccinations include parvo. Until the series is completed dogs are still susceptible. Unvaccinated dogs are susceptible. This virus is extremely contagious and lasts for a very long time in the environment (it can actually overwinter.) And, no vaccine is 100% effective. Booster vaccinations also contain parvo protection

We have achieved "herd immunity" with this disease in most areas so we don't see epidemics like we did in the 1980s, but this virus will probably never be eradicated and will be a potential pathogen for susceptible individuals.

We still see many cases and up to this point have had limited options as far as treatment.

[colliehauler]

Isn't it common to get the parvo shot when getting the rabies shot? Can dogs still get parvo when vaccination against it?