Measure the old hole in the ceiling will give you some info to compare to more modern day.
The current day standard for a travel trailer/Fifth wheels and some MH's, the RV AC unit is a nominal 14 x 14" square opening. They may be 14 1/8 to 14 1/4" actual.
Yes, rebuild with the structure and wiring in place. That same 14 x 14 nominal fits the standard 14 x 14 crank-up roof vent or powered fan, Maxx Air, Fantastic, etc., brands you can install in the hole if you do not have the AC now but want to add it in the future.
Your camper may have ducted AC in the ceiling of the camper, OR if all the air dumps out from the ceiling directly under the roof unit, it is a nonducted unit. If you have ducted AC, the newer AC unit control systems use both 12 VDC to run the controls and 120 VAC to run the fan and compressor. Some of the older ducted AC units created their control voltage from a transformer on the control PC board, and there was no 12 VDC in that area. Upgrading the AC unit later means you had to find 12 VDC and get it to that location. Both new Dometic and Coleman Mach "non-ducted" units use a simple older analog control that does not use 12 VDC. They use a capillary tube control to switch the compressor on and off. You turn the temp control knob like an older auto heater/AC knob.
Point: If your old AC did not use 12 VDC or have the 12-volt wiring near the opening, run a 15 amp, (14 awg wire) 12VDC + and - wire that will be live all the time and fused to the area while you have the roof apart. Just cap/seal off the wire ends to not short. You can use that same DC line to run a vent fan if you do not want to put the AC unit on now. You will only use some of the 15 amps, more like 3 to 5 amps, but you can tap into an existing circuit using little power that can be 15 amp fused already.
I hope this helps, and good luck with your rebuild. I have done many; it will take a lot of time, and if the roof leaks, the water can follow down the walls. The walls may be wet also from siding opening leaks where ever a screw went through or an opening in the side even if the roof did not leak.
These older camper restorations are a true labor of love.
John
2005 Ford F350 Super Duty, 4x4; 6.8L V10 with 4.10 RA, 21,000 GCWR, 11,000 GVWR, upgraded 2 1/2" Towbeast Receiver. Hitched with a 1,700# Reese HP WD, HP Dual Cam to a 2004 Sunline Solaris T310R travel trailer.