Seems like 5 star is one of the more popular tuning options.
I can't take any personal experience with 5star or a "tuned" newer V10 vs stock.
But in general, the couple tuners for n/a gasser trucks I bought/used many moons ago did very little for performance gains. And that is still the case. you're not going to get hardly any more power out of the same engine.
Trans tuning? Idk what could be better. Ford 5 and 6 speed auto transmissions have been pretty spot on for as long as they've been in existence.
Personal opinion, I wouldn't bother.