My opinion—yours may vary:
With a ten speed transmission, a higher numeric ratio axle (ie. 4.30) is not needed. Just put the truck in Tow Haul mode and let it shift. The 3.73 axle will get “slightly” better mileage when not towing while the 4.30 will make little difference when towing (in mileage.) Yes, the 4.30 is rated for a heavier fifth wheel, but the 3.73 is rated for 17,600 or more depending on configuration. While the 4.30 will reduce down shifting from high gear, it won’t do much below high and reduced shifting is one of the goals of Tow Haul mode.