JMO..... but 19.5" tires/wheels and are a commercial service combo made to go the distance at max loads all day and nite long. They will have a shorter sidewall which eliminates carcass roll when properly inflated.
They also can have a G or H load rating 110 psi and comes on our 4500/5500 size trucks. A tall heavy truck camper will benefit from a tire like this. These tires may run twice (or more) as many miles of service than the 18" E tire.
OEM 18"/20" comes up to a load E at 80 psi and do a good job for 2500/3500 pickups with 6k-7k RAWR. They can be a little soft for 4k-6k loads in the bed.