Two 6 volt batteries hand down. Have had both two 12's and two 6's in a number of different RV's over the years and hands down the 6 volt batteries last long when using them. The 6 volt batteries cost more than the 12 volt and they also have a bigger plate size which as have also said others do better on draw down and charging cycles.
If I had the room I would be installing four 6 volt batteries.
Now I am only talking about useing the 6 volt batteries in my camper with a solar panel. For my boat I have one deep cycle battery.
A lot of my buddies with older RV's for hunting will use 12 volt battlers as they are cheaper to buy and they don't have solar systems, and run generators most of the time, so storage capacity of the battery doesn't matter to them. They also use 12 volt so they can interchange the batteries into different rolling stock they have ( cheap buggers... grin)
My truck charges the batteries while it is running and it's doesn't matter what batteries are in the camper as long as they are hooked up correctly.
We do mostly boondocking and have never had an issue with dead batteries since we went to 6 volt.
People can chuck a bunch of numbers out there but I'm going form years of experience only.
Soup.